Between "Family Guy," "American Dad," "The Cleveland Show," "The Orville," and "Ted," Seth MacFarlane has produced countless hours of comedy across animation and live-action. Because he always casts ...

Shameless star William H. Macy was in the running to voice Brian Griffin on Family Guy, but he didn't end up with the gig for a very good reason.

You know Seth MacFarlane’s voice. You’ve heard it a million times as Peter, Brian, and Stewie Griffin. Or maybe as Stan and Roger Smith on “American Dad!” Or maybe as the eponymous bear from the Ted ...

Seth MacFarlane was in great voice when he took the stage at Symphony Hall recently for his sold-out New Year’s Eve concert with the Boston Pops, even if it wasn’t his most familiar voice. A legion of ...