Frank’s sign is a classical examination finding of the ear lobe associated with both heart attack and stroke. A diagonal earlobe crease is characterized by a visible line extending from the tragus to the posterior-inferior edge of the earlobe, typically oriented at approximately a 45-degree angle. The finding may be present on one or both earlobes, with bilateral creases showing a stronger association with systemic disease. While it has been linked to certain cardiovascular risk factors, the ear
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